The efficacy of Thai capsaicin in management of overactive bladder and hypersensitive bladder.

This paper has been generated to provide information on the effectiveness of capsaicin treatment among patients with overactive or hypersensitive bladder. The evaluation process required approximately 14 (overactive bladder) and 11 (hypersensitive bladder and primary detrusor instability) participants who received capsaicin intravesically. The solution consisted of capsaicin (concentration = 1 mM/L) diluted in 30 per cent ethanol solution 100 ml. All participants went through at least 1 urodynamic test 1 month before and after receiving capsaicin intravesical instillation. The capsaicin treatment for overactive and hypersensitive bladders was very effective. On the average, (overactive bladder) participants' voiding needs decreased from 16.5 +/- 4.8 times/day to 8.6 +/- 2.5 times/day, leakage from 9.7 +/- 8.1 times/day to 2.4 +/- 4.3 times/day, bladder capacity from 160.1 +/- 123.3 ml to 236.9 +/- 146.1 ml, and detrusor contraction from 71.1 +/- 29.2 cm/H2O to 57.3 +/- 27.2 cm/H2O. On average, (hypersensitive bladder and primary detrusor instability) participants' voiding needs decreased from (Day time) 19.45 +/- 17.99 times to 12.00 +/- 8.91 times/day, (Night time) 7.09 +/- 6.03 times to 4.09 +/- 3.8 times, bladder capacity from 197.40 +/- 156.06 ml to 323.45 +/- 129.46 ml, and detrusor contraction from 32.64 +/- 22.77 cm/H2O to 36.64 +/- 19.22 cm/H2O. Capsaicin efficiency was rated very high for both overactive and hypersensitive bladder and primary detrusor instability. In Thailand, it has been possible to produce capsaicin using local chili supplies, thus the price of the drug itself is very economical. When considering the efficiency and the inexpensive cost of capsaicin, this treatment would be another great alternative for overactive and hypersensitive bladder cure.

The efficacy of Thai capsaicin in the treatment of primary detrusor instability and hypersensitive bladder.

Our an objective was to study the efficacy of Capsaicin extracted from Capsaicin frutescen in treating the patients with hypersensitive bladder and primary detrusor instability. Eleven patients, 3 males and 8 females, with average age of 60.3ฑ14.3 years were treated by intravesical instillation 1 mM/L Capsaicin in 30% ethanol in an amount half of the bladder capacity for 30 minutes after instillation 2% xylocaine without adrenaline for 15 minutes three out of the 11 patients who could not tolerate the pain by this method were anesthesized with regional or general anesthesia. The results were as follow :- 1. Clinical symptoms were improved significantly, i e. the frequency was reduced from day : night = 19.45ฑ17.99 : 7.09ฑ6.30 to 12.00ฑ8.91 : 4.09ฑ3.8 at p < 0.05 and leakage almost disappeared. 2. Maximal bladder capacity increased from 197.45ฑ156.06 ml to 323.45ฑ129.46 ml which was statistically significant (p=0.009). 3. Detrusor pressure at maximal bladder capacity increased from 32.63ฑ22.76 cmH2O to 36.63ฑ19.21 cmH2O but was not statistically significant (P=0.823). 4. Voiding pressure nonsignificantly increased from 47.1ฑ6.4 cmH2O to 48.1ฑ6.6 cmH2O (p=0.959). The adverse effects found were burning pain at suprapubic area, sweating and hematuria.

The efficiency of capsaicin in overactive bladder.

Our objective was to treat the overactive bladder caused by Detrusor hyperreflexia (in suprasacral cord neuropathic bladder) and Detrusor instability (idiopathic) by Capsaicin that was extracted from Capsicum Frutes Cens. Eleven with patients neuropathic bladder and three patients with idiopathic Detrusor instability were enrolled. They were treated by intravesical Capsiacin at a concentration of 1 mM/L in 30% ethanol to half of the bladder capacity for 30 minutes after 2% Xylocaine without adrenaline up to half of the bladder capacity for 15 minutes. The results showed significant improvement ie. Average frequency reduced from 16.5 + 4.8 time/day to 8.6 + 2.5 time/ day Average leakage reduced from 9.7 + 8.1 time/day to 2.4 + 4.3 time/day Urodynamic results Pressure at maximal bladder capacity reduced from 71.1 + 29.2 cmH2O to 57.3 + 27.2 cmH2O Voiding pressure reduced from 74.8 + 35.3 cmH2O to 65.1 + 35.0 cmH2O

Quantitative analysis of prednisolone and dexamethasone in modified herbal drugs.

Quantitative analysis of prednisolone and dexamethasone in modified herbal drugs were performed by using thin layer chromatography in comparison to coloimetric method. From all 126 samples collected, 36 samples prednisolone was found, dexamethasone in 10 samples and both steroids were found in another 11 samples. These modified herbal drugs were mainly used for the treatment of asthma and pain relief in arthritis; others were used for skin disease, cancer and appetite stimulant.